Figure 5.

Genes with the most variants of uncertain significance across the context of hereditary cancer versus other diseases

Results are shown for hereditary cancer (A) and other diseases (B). Variant records that were not matched to a variant or had no ACMG/AMP¹¹ criteria assigned were removed, and only the most recently curated record was included if more than one variant record for a variant had been submitted by the same laboratory. All records that had a strength assigned for BS3 or PS3 were also excluded. Results for the hereditary cancer genes were driven by one laboratory.