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. 2022 Sep 30;121(21):4063–4077. doi: 10.1016/j.bpj.2022.09.038

Table 3.

Isothermal titration calorimetry of insulins against IR485 with an αCT peptidea

Insulin analog αCT peptide KD (nM) ΔH (kJ mol−1) TΔS (kJ mol−1)
HI IR-A αCT704–719 30.5 ± 5.4 -63.6 ± 9.6 −20.5 ± 9.2
IR-B αCT704–731 37.3 ± 5.3 −58.3 ± 2.1 −15.1 ± 2.1
SCI-b IR-A αCT704–719 20.1 ± 8.4 −90.0 ± 0.4 −45.6 ± 1.3
IR-B αCT704–731 160.6 ± 6.5 −94.6 ± 1.7 −56.1 ± 1.7
a

Data are from three technical replicates; errors are SEM. For further details, see materials and methods.