Table 2.
Multivariable analysis: Interaction between BMI as a continuous variable and donor type*
| Label | Hazard Ratio | 95% Hazard Ratio Confidence Limits | Adjusted P-value‡ | |
|---|---|---|---|---|
| NRM | 1.000 | <.0001 | ||
| Haplo vs MUD at BMI = 20 | 1.250 | 0.882 | 1.770 | 0.4923 |
| Haplo vs MUD at BMI = 25 | 1.318 | 1.015 | 1.710 | 0.1557 |
| Haplo vs MUD at BMI = 30 | 1.375 | 1.065 | 1.775 | 0.0724 |
| Haplo vs MUD at BMI = 35 | 1.224 | 0.920 | 1.628 | 0.4632 |
| Haplo vs MUD at BMI = 40 | 1.082 | 0.723 | 1.618 | 0.7314 |
| Haplo vs MUD at BMI = 45 | 1.279 | 0.638 | 2.567 | 0.7314 |
| CBU vs Haplo at BMI = 20 | 1.152 | 0.711 | 1.868 | 0.5652 |
| CBU vs Haplo at BMI = 25 | 1.712 | 1.175 | 2.494 | 0.0250 |
| CBU vs Haplo at BMI = 30 | 1.657 | 1.135 | 2.418 | 0.0375 |
| CBU vs Haplo at BMI = 35 | 1.319 | 0.862 | 2.020 | 0.3711 |
| CBU vs Haplo at BMI = 40 | 1.514 | 0.836 | 2.742 | 0.3711 |
| CBU vs Haplo at BMI = 45 | 2.709 | 0.971 | 7.561 | 0.1852 |
| CBU vs MUD at BMI = 20 | 1.440 | 0.991 | 2.092 | 0.0882 |
| CBU vs MUD at BMI = 25 | 2.256 | 1.699 | 2.995 | <.0001 |
| CBU vs MUD at BMI = 30 | 2.278 | 1.705 | 3.043 | <.0001 |
| CBU vs MUD at BMI = 35 | 1.615 | 1.155 | 2.258 | 0.0166 |
| CBU vs MUD at BMI = 40 | 1.638 | 1.010 | 2.656 | 0.0882 |
| CBU vs MUD at BMI = 45 | 3.466 | 1.470 | 8.175 | 0.0166 |
| OS | 1.000 | 0.0002 | ||
| Haplo vs MUD at BMI = 20 | 1.231 | 0.985 | 1.538 | 0.1857 |
| Haplo vs MUD at BMI = 25 | 1.267 | 1.069 | 1.503 | 0.0334 |
| Haplo vs MUD at BMI = 30 | 1.263 | 1.068 | 1.494 | 0.0334 |
| Haplo vs MUD at BMI = 35 | 1.215 | 1.008 | 1.465 | 0.1397 |
| Haplo vs MUD at BMI = 40 | 1.133 | 0.869 | 1.477 | 0.5802 |
| Haplo vs MUD at BMI = 45 | 1.154 | 0.735 | 1.812 | 0.5802 |
| CBU vs Haplo at BMI = 20 | 0.856 | 0.611 | 1.201 | 0.6337 |
| CBU vs Haplo at BMI = 25 | 1.446 | 1.105 | 1.891 | 0.0350 |
| CBU vs Haplo at BMI = 30 | 1.389 | 1.056 | 1.828 | 0.0762 |
| CBU vs Haplo at BMI = 35 | 1.176 | 0.864 | 1.600 | 0.6337 |
| CBU vs Haplo at BMI = 40 | 1.357 | 0.891 | 2.067 | 0.4364 |
| CBU vs Haplo at BMI = 45 | 1.512 | 0.662 | 3.450 | 0.6337 |
| CBU vs MUD at BMI = 20 | 1.054 | 0.800 | 1.389 | 0.7090 |
| CBU vs MUD at BMI = 25 | 1.832 | 1.478 | 2.271 | <.0001 |
| CBU vs MUD at BMI = 30 | 1.755 | 1.403 | 2.195 | <.0001 |
| CBU vs MUD at BMI = 35 | 1.429 | 1.105 | 1.847 | 0.0235 |
| CBU vs MUD at BMI = 40 | 1.537 | 1.075 | 2.197 | 0.0537 |
| CBU vs MUD at BMI = 45 | 1.744 | 0.826 | 3.683 | 0.2630 |
| DFS | 1.000 | 0.0002 | ||
| Haplo vs MUD at BMI = 20 | 1.130 | 0.933 | 1.369 | 0.5003 |
| Haplo vs MUD at BMI = 25 | 1.191 | 1.029 | 1.377 | 0.0927 |
| Haplo vs MUD at BMI = 30 | 1.172 | 1.015 | 1.353 | 0.1238 |
| Haplo vs MUD at BMI = 35 | 1.144 | 0.974 | 1.343 | 0.3134 |
| Haplo vs MUD at BMI = 40 | 1.065 | 0.846 | 1.341 | 0.8300 |
| Haplo vs MUD at BMI = 45 | 1.022 | 0.680 | 1.536 | 0.9184 |
| CBU vs Haplo at BMI = 20 | 0.832 | 0.613 | 1.129 | 0.6028 |
| CBU vs Haplo at BMI = 25 | 1.187 | 0.927 | 1.519 | 0.5361 |
| CBU vs Haplo at BMI = 30 | 1.211 | 0.942 | 1.557 | 0.4742 |
| CBU vs Haplo at BMI = 35 | 1.023 | 0.772 | 1.356 | 0.8748 |
| CBU vs Haplo at BMI = 40 | 1.115 | 0.754 | 1.649 | 0.7980 |
| CBU vs Haplo at BMI = 45 | 1.343 | 0.623 | 2.894 | 0.7980 |
| CBU vs MUD at BMI = 20 | 0.940 | 0.727 | 1.215 | 0.6835 |
| CBU vs MUD at BMI = 25 | 1.413 | 1.150 | 1.735 | 0.0054 |
| CBU vs MUD at BMI = 30 | 1.419 | 1.147 | 1.755 | 0.0057 |
| CBU vs MUD at BMI = 35 | 1.170 | 0.919 | 1.490 | 0.5420 |
| CBU vs MUD at BMI = 40 | 1.188 | 0.844 | 1.671 | 0.6835 |
| CBU vs MUD at BMI = 45 | 1.372 | 0.681 | 2.764 | 0.6835 |
NRM, non-relapse mortality; BMI, body mass index; haplo, haploidentical related donor transplant; MUD, matched unrelated donor transplant; CBU, cord blood unit; OS, overall survival; DFS, disease-free survival.
*
adjusting for age, KPS, HCT-CI, disease and disease risk, donor-recipient CMV sero-status, GVHD prophylaxis, conditioning intensity, in vivo T cell depletion.