Table 2.

Structure–Activity Relationship (SAR) on the 4-Sulfamoylbenzamide Moiety with the Main Focus on Position R² to Enter the ATP-Binding Pocket. Binding of the substituted sulfamoylbenzamide derivatives (compounds 28–32) to LIMK1/2 as determined by DSF and NanoBRET^a

^aΔTm shifts are reported as means of three independent experiments. IC₅₀ values for LIMK1 and LIMK2 were determined in a cellular assay system using NanoBRET. IC₅₀ values are reported as means ± SD of three independent experiments.