Table 2. Results of Meta-analysis for Pregnancy Outcomes in Women with Subclinical Hyperthyroidism Compared to Euthyroid Controls (With and Without Application of Trim and Fill Method).
| Outcomes | P-Value, Egger Test | I-squared% | Pooled Odds Ratio (95% CI) | Pooled Odds Ratio (95% CI) via Trim and Fill Method |
|---|---|---|---|---|
| Hypertensive disorders | 0.031 a | 33.0 | 0.839 0.615 1.143 | 0.684 0.466 1.002 |
| Preterm delivery | 0.144 | 0.0 | 0.963 0.739 1.253 | -- |
| Macrosomia/ LGA | 0.847 | 0.0 | 0.885 0.673 1.165 | -- |
| Pregnancy loss | 0.681 | 0.0 | 1.668 0.728 3.822 | -- |
| Adverse maternal outcomes | 0.001 a | 0.0 | 1.133 0.802 1.600 | 0.760, 0.514, 1.123 |
| Adverse neonatal outcomes | 0.008 a | 0.0 | 1.781 1.026 3.091 | 1.055, 0.597, 1.863 |
| Adverse fetal outcomes | 0.001 a | 0.0 | 1.095 0.911 1.317 | 0.953, 0.747, 1.215 |
Abbreviation: LGA, large for gestational age
a Statistical significance level P < 0.05