Table 2.
Comparison of exhaustion-related performance in patients between the survival and non-survival group
| Parameters | All patients n = 62 | Survivors n = 45 | Non-survivors n = 17 | p-Value |
|---|---|---|---|---|
| Lymphocytes percentage (%), median (IQR) | 9.60(5.80-18.83) | 11.80(7.05-19.55) | 6.70(3.80-9.25) | 0.023 |
| Lymphocytes (×10^9/L), mean (SD) | 1.11(0.65) | 1.22(0.62) | 0.83(0.65) | 0.034 |
| CD8+ T cell percentage (%), mean (SD) | 11.53(8.00) | 13.36(7.89) | 6.68(6.19) | 0.003 |
| CD8+ T cell(×10^6/L), mean (SD) | 216.15(188.97) | 254.70(204.62) | 106.00(55.16) | 0.007 |
| Cell proliferation ratio, mean (SD) | 0.87(0.41) | 1.01(0.38) | 0.64(0.35) | 0.045 |
| IFN-γ (pg/ml), mean (SD) | 14.46(13.69) | 12.70(13.43) | 20.65(13.95) | 0.214 |
| TNF-α (pg/ml), mean (SD) | 7.88(7.08) | 7.44(7.60) | 9.39(5.12) | 0.563 |
| PD-1in CD8+ T cell (%), mean (SD) | 15.46(14.88) | 13.02(12.42) | 21.93(18.93) | 0.034 |
| Tim-3 in CD8+ T cell (%), mean (SD) | 19.03(16.24) | 15.47(14.20) | 28.43(17.94) | 0.004 |
Abbreviations: IQR Interquartile Range, SD Standard Deviation, TNF-α Tumor necrosis factor-alpha, IFN-γ Interferon-gamma, PD-1 Programmed Cell Death 1,Tim-3 T-cell immunoglobulin mucin-3