Table 2.
Characteristics of maternal IgG transplacentally transferred to babies
| Amount of Ab MFI at day 9 ± 2 (median, 1st, 3rd quartile) | Percentage of Ab-positive Babiesa | Ab Half-life, ± 95% CI (months)b | Length of detectable maternal IgG (months) | |
|---|---|---|---|---|
| AMA1 (3D7) | 11,757 (8,765, 14,108) | 96.9 | 1.46 (1.17, 1.94) | 6 |
| AMA1 (FVO) | 12,581 (10,218, 14,870) | 96.9 | 1.88 (1.4, 2.59) | 8 |
| EBA-175 | 10,800 (3,635, 12,460) | 79.7 | 0.98 (0.83,1.21) | 6 |
| MSP1-42 (3D7) | 1,003 (10, 3,868) | 35.9 | NCc | NC |
| MSP1-42 (FVO) | 4,637 (615, 11,207) | 67.2 | NC | 3 |
| MSP2 (3D7) | 6,235 (2,298, 10,163) | 76.6 | 0.78 (0.67, 0.92) | 3 |
| MSP2 (FC27) | 6,935 (2,325, 10,163) | 81.3 | 0.73 (0.64, 0.86) | NC |
| MSP3 | 239 (0, 1,482) | 31.3 | 2.41 (1.58, 5.04) | NC |
| RESA | 0 (0, 0) | 0 | NC | NC |
| LSA-1 | 0 (0, 218) | 23.4 | NC | NC |
| CSP | 0 (0, 352) | 25.0 | 2.39 (1.64, 4.36) | NC |
aPercent of babies at 9 ± 2 days with MFI above cut-off: AMA1(3D7) 1,970 MFI; AMA1 (FVO) 2,050 MFI; EBA-175 (2,020 MFI; MSP1(3D7) 1,500MFI; MSP1(FVO) 1,800 MFI; MSP2(3D7) 1,980 MFI; MSP2(FC27) 1,880 MFI; MSP3 842 MFI; RESA 390 MFI; LSA-1 380 MFI; CSP 490 MFI
bbased on IgG Ab levels between Day 9 ± 2 after birth until 6 months of age
cNot calculatable, because no consistent decline occurred or Ab were produced prior to 6 months