Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 19;22:362. doi: 10.1186/s12935-022-02771-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Blockade of CCL2/CCR2 and CXCL1/CXCR2 enhances the antitumor effect of TACE in the HCC model. A Sprague Dawley rats were treated with diethylnitrosamine for 14 weeks, then subjected to the modified TACE procedure. The chemotherapeutic drug cisplatin (3 mg/kg body weight) was administered to the TACE-treated rats with or without the CCR2 antagonist INCB3344 (60 μg/g body weight) and the CXCR2 antagonist SCH527123 (10 μg/g body weight). Control animals received the TACE procedure and administered 0.5 ml normal saline. Representative images of rat livers from the indicated treatment groups are shown. Typical tumor nodes are indicated by the asterisks (n = 10/group). B The number of HCC nodules per liver. Data are presented as mean ± SD. ns, not statistically significant, ***p < 0.001. C The maximum tumor volume per liver. Data are presented as mean ± SD. ns, not statistically significant, ***p < 0.001. D Hematoxylin and eosin H, E staining was employed to observe the histological structure of the liver in the indicated groups. Black asterisks represent accumulation of inflammatory cells. Scale bar, 200 μm. E The Klintrup-Makinen score was determined to assess the level of local inflammatory cell infiltration. Data are presented as mean ± SD. ns not statistically significant, ***p < 0.001