Fig. 6.

Ly-6C^hi cells are a good biomarker for the efficacy of fingolimod treatment in EAE. A The higher the Ly-6C^hicell content at onset, the greater the difference in the maximum score reached by EAE-FTY720 mice compared to the median of the EAE-Veh group. B, D ROC curve analysis showing that Ly-6C^hi cells had a good capacity to discriminate high efficacy as opposed to low efficacy EAE mice through the median accumulated clinical score (B) and the residual score (D). C, E Cut-off values for the Ly-6C^hi cells/total blood cells to predict those EAE mice that will present a higher total accumulated or a lower residual score than the median of EAE-FTY720 mice at the end of the experimental evaluation