Table 1.
Comparison of the clinical parameters and splenic T cell populations in EAE mice following individualized treatment with fingolimod or vehicle
| Vehicle | FTY720 | p value | |
|---|---|---|---|
| Clinical parameters | |||
| Maximum score | 3 (2.25–3) | 2.38 (1.18–2.75) | < 0.05 |
| dpi peak | 15 (14–17) | 15 (14–15.25) | ns |
| Severity index | 0.75 (0.50–1.00) | 0.625 (0.33–0.75) | ns |
| Peak accumulated score | 6.50 (5.63–9.00) | 5.69 (3.68–6.81) | ns |
| Total accumulated score | 37.25 (23.00–42.38) | 18.88 (12.59–27.16) | < 0.01 |
| % Recovery | 25.00 (12.50–33.30) | 72.73 (53.41–80.24) | < 0.01 |
| Recovery index | 0.093 (0.04–0.17) | 0.16 (0.10–0.21) | < 0.05 |
| Residual score | 2.25 (1.00–2.63) | 0.50 (0.50–0.88) | < 0.01 |
| Spleen | |||
| % CD3+/Total blood cells | 15.15 ± 0.97 | 11.06 ± 0.93 | < 0.01 |
| % CD4+/Total blood cells | 9.11 ± 0.64 | 7.75 ± 0.63 | ns |
| % CD8+/Total blood cells | 4.98 ± 0.36 | 2.79 ± 0.28 | < 0.001 |
| % CD3+CD25+/Total blood cells | 1.32 ± 0.08 | 1.09 ± 0.07 | < 0.05 |
| % CD3+CD69+/Total blood cells | 1.77 ± 0.12 | 1.86 ± 0.10 | ns |
The data are expressed as the median (IQR) for the clinical parameters and the mean ± SEM for the splenic parameters. The results of applying a Student’s t-test or a non-parametric Mann–Whitney test are shown: dpi day post-immunization; IQR interquartile range; ns non-significant