Table 3.
Comparison of the clinical parameters and splenic T cell populations in EAE-Vehicle, and EAE-FTY720 responder and non-responder mice
| EAE-Vehicle | EAE-FTY720 | p value | ||
|---|---|---|---|---|
| Non-responder | Responder | |||
| Clinical parameters | ||||
| Maximum score |
3 (2.25–3) |
3 (3–3) |
2.25* (1.25–2.63) |
< 0.01 |
| dpi peak |
15 (14–17) |
15 (13–15) |
15 (14–16) |
ns |
| Severity index |
0.75 (0.50–1) |
0.75 (0.60–1) |
0.63 (0.33–0.69) |
ns |
| Peak accumulated score |
6.5 (5.63–9) |
7 (6.50–9.75) |
4.5* (3–6.63) |
< 0.05 |
| Total accumulated score |
37.25 (23–45.38) |
41.38 (34.38–45.50) |
18* (10.90–24.75) |
< 0.001 |
| % Recovery |
25 (12.5–33.30) |
8.33 (0–25) |
75* (62.50–80.95) |
< 0.001 |
| Recovery index |
0.09 (0.04–0.17) |
0.04 (0–0.09) |
0.17* (0.13–0.22) |
< 0.01 |
| Residual score |
2.25 (1–2.63) |
2.75 (2.25–3) |
0.5* (0.5–0.75) |
< 0.001 |
| Spleen | ||||
| % CD3+/Total blood cells | 15.15 ± 0.97 | 15.68 ± 3.27 | 10.13 ± 0.77* | < 0.01 |
| % CD4+/Total blood cells | 9.11 ± 0.64 | 10.51 ± 2.17 | 7.20 ± 0.56* | < 0.05 |
| % CD8+/Total blood cells | 4.98 ± 0.36 | 4.47 ± 0.91 | 2.46 ± 0.21* | < 0.001 |
| % CD3 CD25+/Total blood cells | 1.32 ± 0.08 | 1.33 ± 0.25 | 1.04 ± 0.07* | < 0.05 |
| % CD3 CD69+/Total blood cells | 1.77 ± 0.12 | 2.24 ± 0.31 | 1.78 ± 0.10 | ns |
The data are expressed as the median (IQR). One-way ANOVA or a non-parametric ANOVA on ranks tests are shown: dpi day post-immunization; ns not significant; IQR interquartile range
*Represents significantly different groups