Table 3.

Effects of the Hydromethanolic Crude Extract and Solvent Fractions of the Roots of Acacia seyal on Castor Oil-Induced Enteropooling in Mice

Extracts	Dose Administered	Mean Weight of Small Intestinal Content (g)	% Inhibition	Mean Volume of Small Intestinal Content (mL)	% Inhibition
HMeOH	CON	0.84±0.04	–	0.97±0.05	–
	100 mg/kg	0.38±0.06a***	54.76	0.52±0.03a***	46.39
	200 mg/kg	0.26±0.02a***	69.05	0.29±0.03a***b***	70.10
	400 mg/kg	0.21±0.02a***b*	75.00	0.25±0.02a***b***	74.23
	Loperamide 3 mg/kg	0.20±0.02a***	76.20	0.24±0.03a***	75.26
Solvent fraction	CON	0.81±0.03	–	0.93±0.03	–
	AQ 100 mg/kg	0.58±0.04	28.39	0.70±0.04	24.73
	AQ 200 mg/kg	0.56±0.02a*	30.86	0.69±0.04a*	25.80
	AQ 400 mg/kg	0.48±0.03a**	40.74	0.68±0.06a*	26.88
	CON	0.80±0.03	–	092±0.03	–
	EA 100 mg/kg	0.46±0.14a***	42.50	0.66±0.08a*	28.26
	EA 200 mg/kg	0.35±0.02a***	56.25	0.41±0.05a***h*	55.43
	EA 400 mg/kg	0.25±0.02a***	68.75	0.30±0.05a***h***	67.39
	n-HE 100 mg/kg	0.37±0.03a***	53.75	0.50±0.04a***	45.65
	n-HE 200 mg/kg	0.29±0.04a***	63.75	0.30±0.03a***h***	67.39
	n-HE 400 mg/kg	0.22±0.01a***	72.50	0.27±0.04a***h***	70.65
	Loperamide 3 mg/kg	0.21±0.02a***	73.75	0.26±0.03a***	71.74

Notes: Data are expressed as mean ± SEM (n=6); ^acompared with negative control, ^bcompared with 100 mg/kg HMeOH, ^hcompared with 100 mg/kg EA. *p<0.05, ** p<0.01, ***p<0.001.

Abbreviations: MeOH, methanolic crude extract; n-HE, n-Hexane fraction; EA, Ethyl acetate fraction; AQ, Aqueous fraction; CON, Negative control received 1mL/100g distilled water for MeOH extract, n-hexane, ethyl acetate and aqueous fractions.