. 2022 Nov 15;14:99–110. doi: 10.2147/CPAA.S383896

Table 4.

Effects of Hydromethanolic Crude Extract and Solvent Fractions of the Roots of Acacia seyal on Castor Oil-Induced Gastrointestinal Motility in Mice

	Dose Administered	Length of the Small Intestine (cm)	Distance Moved by Charcoal Meal (cm)	Peristaltic Index (%)	% Inhibition
HMeOH	CON	57.82±1.48	44.53±1.03	77.02±0.55	–
	100 mg/kg	53.33±2.90	26.00±1.37^a***	48.75±4.24^a***	36.70
	200 mg/kg	52.30±1.89	15.10±1.46^a*b*	28.87±2.88^a*b*	62.52
	400 mg/kg	58.28±3.12	8.83±1.08^a*bc*	15.15±1.90^a*bc*	80.33
	Atropine 5mg/kg	59.47	7.50±0.76^a***	12.61±1.08^a***	83.63
Solvent fractions	CON	56.79±1.63	42.58±2.72	75.00±4.97	–
	AQ 100 mg/kg	55.52±.76	41.08±3.39	73.99±3.24	1.36
	AQ 200 mg/kg	56.63±1.49	37.98±3.04	67.07±6.67	10.59
	AQ 400 mg/kg	58.97±1.00	29.83±2.63^a*e	50.59±5.13^a*e	32.56
	CON	56.83±1.65	42.63±2.74	75.01±4.99	–
	EA 100 mg/kg	55.62±1.02	34.42±2.00	61.88±3.75	17.50
	EA 200 mg/kg	55.97±0.97	28.17±1.76^a**	50.33±3.71^a**	32.90
	EA 400 mg/kg	56.65±1.43	18.60±2.04^a*h*	32.83±3.62^a*h*	56.23
		55.63±1.17	26.33±2.16^a***	47.33±3.48^a**	36.90
	n-HE 200 mg/kg	57.10±1.41	18.20±1.51^a*h*	31.87±2.67^a*h*	57.51
	n-HE 400 mg/kg	58.22±1.49	10.58±1.36^{a*hik*}	18.17±2.58^{a*hik}	75.78
	Atropine 5 mg/kg	58.25±1.12	10.57±0.76^a***	18.15±1.40^a***	75.80

Notes: Data are expressed as mean ± SEM (n=6); ^acompared with negative control, ^bcompared with 100 mg/kg HMeOH, ^ccompared with 200 mg/kg HMeOH, ^ecompared with 100 mg/kg AQ, ^hcompared with 100 mg/kg EA, ⁱcompared with 200 mg/kg EA, ^kcompared with 100 mg/kg n-HE. *p<0.05, **p<0.01, ***p<0.001.

Abbreviations: HMeOH, Methanolic crude extract; n-HE, n-Hexane fraction; EA, Ethyl acetate fraction; AQ, Aqueous fraction; CON, Negative control received 1mL/100g distilled water for MeOH extract, n-hexane, ethyl acetate and aqueous fractions.