. 2022 Nov 15;16:3753–3762. doi: 10.2147/OPTH.S388982

Table 2.

Special Populations and/or Conditions of Special Care with the Use of Cyclopentolate

Condition	Effect
Children Neonates Premature²¹^,⁶⁸^,⁷⁶^,⁸²^,⁸⁴^,⁹²	Cardiovascular, nervous, digestive, metabolic and excretory system immaturity
	Lower blood volume
	Increase brain–blood permeability
Geriatrics⁶⁸^,⁹²	Impaired nervous system
Epilepsy Brain damage Down’s syndrome⁶⁸^,⁷⁶^,⁸³^,⁸⁴^,⁸⁶^,⁹⁴^,¹⁰²	Disjointed stimulation of the nervous system
Mutant pseudocholinesterase Low activity or serum level of pseudocholinesterase⁷¹^,⁷⁶^,¹⁰³	Decreased metabolism of cyclopentolate
Glaucoma Narrow anterior chamber¹^,⁶⁸^,⁸⁴^,¹⁰⁴^,¹⁰⁵	May interfere with anti-glaucoma action of carbachol or pilocarpine
Glaucoma Narrow anterior chamber¹^,⁶⁸^,⁸⁴^,¹⁰⁴^,¹⁰⁵	Significant changes in anterior chamber structure and anterior segment angle
Use of substances with a central nervous system effect⁶⁸^,⁸⁵	Interference with the cholinergic system