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. 2022 Nov 15;15:6307–6328. doi: 10.2147/JIR.S383239

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© 2022 Liang et al.

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TPP-CeO₂ NPs acted as antioxidants for AD. (A) Formations of oxygen vacancies, cerium(III) and cerium(IV) species in CeO₂ NPs. (B) Main roles of components on edaravone-carried and PEG/ANG-conjugated CeO₂ NPs (E-A/P-CeO₂). (C) Synthetic process for E-A/P-CeO₂. (D) ANG-LRP endocytosis of E-A/P-CeO₂. Reprinted with permission from Bao Q, Hu P, Xu Y et al. Simultaneous blood-brain barrier crossing and protection for stroke treatment based on edaravone-loaded ceria nanoparticles. ACS Nano. 2018;12(7):6794–6805. Copyright (2018) American Chemical Society.⁶²