Table 1.

Representative Antioxidant Nanozymes and Their Applications

Nanozymes	Activity/Mechanism	Application	Reference
Fullerenes	·OH and O2·− scavenging activity	Cardiac functional recovery	[31]
		Allergic response	[165]
		Doxorubicin-induced hepatotoxicity	[166]
Graphene based NPs	·OH and O2·− scavenging activity Catalase	Neuroprotection	[34]
		Cardiac repair	[36]
		Acute kidney injury	[134]
Fe3O4 NPs	Peroxidase Catalase	Aging	[39]
		Neurodegeneration	[39]
		Cerebral malaria	[167]
PBNPs	Peroxidase Catalase SOD	Colitis	[43]
		Acute pancreatitis	[47]
		Full-thickness skin wound	[48]
		Ischemic Stroke	[49]
CeO2 NPs	Catalase SOD Oxidase	Ischemic stroke	[62,63]
		AD	[64–66]
		Depression	[67]
		IBD	[69]
		Acute gout	[70]
		Drug-induced liver injury	[73]
		PD	[75]
		Rheumatoid arthritis	[168]
		Traumatic brain injury	[169]
Mn3O4 NPs	SOD Catalase GPx	Ear inflammation	[82]
		PD	[84]
		IBD	[170]
Cu based NPs	Peroxidase SOD Catalase GPx	Acute kidney injury, acute liver injury, wound healing	[20]
		PD	[79]
Mo based NPs	SOD Catalases Peroxidases	Acute kidney injury	[162]
		Hepatic fibrosis	[171]
Pt NPs	SOD Catalases Peroxidases	Pulmonary inflammation	[172]
		Hepaticischemia/reperfusion injury	[173]
Melanin-like NPs	·OH, O2·−, H2O2, NO, and ONOO− scavenging activity	Ischemic stroke	[153]
		Periodontal disease	[150]
		Osteoarthritis	[148]
		Acute peritonitis and acute lung injury	[174]
MOF based NPs	SOD Catalase	Endotoxemia	[97]
		IBD	[175]