Table 3:
Logistic Regression Analysis Assessing the Association between Tumor Infiltrating Lymphocytes and Serum Carotenoids [OR(95%CI)]
| Tumor Infiltrating Lymphocytes (TILs) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjustedǂ | |||||||
| CD4 | CD8 | CD68 | FOXP3 | CD4 | CD8 | CD68 | FOXP3 | |
| Sample Size | 69 | 69 | 68 | 70 | 69 | 69 | 68 | 70 |
| Alpha Carotene | ||||||||
| Low (≤ 0.01 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>0.01 ug/ml) | 1.48 (1.01, 2.18) | 2.25 (1.53, 3.30) | 0.86 (0.59, 1.25) | 1.54 (1.05, 2.25) | 1.05 (0.64, 1.70) | 1.05 (0.65, 1.71) | 0.53 (0.33, 0.85) | 0.44 (0.25, 0.79) |
| p-value | 0.05 | <.0001 | 0.42 | 0.03 | 0.85 | 0.84 | 0.01 | 0.01 |
| Beta Carotene | ||||||||
| Low (≤0.03 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>0.03 ug/ml) | 0.91 (0.62, 1.34) | 1.51 (1.03, 2.20) | 1.08 (0.74, 1.57) | 1.13 (0.78, 1.65) | 0.74 (0.47, 1.17) | 0.95 (0.59, 1.53) | 0.91 (0.58, 1.40) | 0.48 (0.29, 0.82) |
| p-value | 0.64 | 0.03 | 0.70 | 0.52 | 0.19 | 0.83 | 0.66 | 0.01 |
| Xanthophylls | ||||||||
| Low (≤0.13 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>0.13 ug/ml) | 1.17 (0.80, 1.71) | 0.98 (0.67, 1.43) | 0.21 (0.14, 0.32) | 0.93 (0.64, 1.36) | 0.73 (0.45, 1.18) | 0.58 (0.35, 0.96) | 0.12 (0.07, 0.21) | 0.91 (0.55, 1.51) |
| p-value | 0.43 | 0.92 | <.0001 | 0.72 | 0.20 | 0.03 | <.0001 | 0.71 |
| Lycopene | ||||||||
| Low (≤0.04 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>0.04 ug/ml) | 0.83 (0.56, 1.21) | 1.51 (1.03, 2.20) | 0.53 (0.36, 0.78) | 1.18 (0.81, 1.73) | 0.70 (0.43, 1.14) | 0.47 (0.27, 0.81) | 0.36 (0.22, 0.61) | 1.02 (0.59, 1.75) |
| p-value | 0.33 | 0.03 | 0.001 | 0.38 | 0.15 | 0.01 | 0.0001 | 0.95 |
| Total* | ||||||||
| Low (≤0.24 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>0.24 ug/ml) | 0.90 (0.61, 1.32) | 1.23 (0.85, 1.80) | 0.46 (0.31, 0.67) | 0.80 (0.55, 1.17) | 0.61 (0.37, 1.02) | 0.44 (0.26, 0.75) | 0.31 (0.19, 0.51) | 0.56 (0.32, 0.97) |
| p-value | 0.57 | 0.27 | <.0001 | 0.25 | 0.06 | 0.003 | <.0001 | 0.04 |
| Alpha tocopherol | ||||||||
| Low (≤8.42 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>8.42 ug/ml) | 2.34 (1.59, 3.46) | 2.09 (1.43, 3.06) | 1.30 (0.89, 1.89) | 1.68 (1.15, 2.44) | 1.61 (1.00, 2.60) | 1.68 (1.04, 2.71) | 0.94 (0.60, 1.47) | 1.08 (0.65, 1.80) |
| p-value | <.0001 | 0.0001 | 0.17 | 0.01 | 0.05 | 0.03 | 0.78 | 0.77 |
| Gamma tocopherol | ||||||||
| Low (≤1.09 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>1.09 ug/ml) | 0.69 (0.47, 1.02) | 1.49 (1.02, 2.17) | 1.54 (1.05, 2.24) | 1.45 (1.00, 2.11) | 0.73 (0.46, 1.15) | 2.21 (1.37, 3.56) | 1.89 (1.22, 2.93) | 4.26 (2.40, 7.58) |
| p-value | 0.06 | 0.04 | 0.03 | 0.05 | 0.18 | 0.001 | 0.004 | <.0001 |
| Total tocopherol ¥ | ||||||||
| Low (≤9.44 ug/ml) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) | (Ref) |
| High (>9.44 ug/ml) | 1.79 (1.22, 2.64) | 1.60 (1.10, 2.33) | 1.12 (0.77, 1.62) | 1.29 (0.89, 1.88) | 1.25 (0.78, 1.99) | 1.44 (0.90, 2.30) | 0.96 (0.62, 1.49) | 0.93 (0.56, 1.54) |
| p-value | 0.003 | 0.01 | 0.56 | 0.18 | 0.35 | 0.13 | 0.86 | 0.78 |
*
calculates as: alpha carotene+beta carotene+xanthophylls+lycopene
¥
calculated as: alpha tocopherol+gamma tocopherol
ǂ
Age, sex, disease site and TMA adjusted