Table 1 -.
Summary of demographic, clinical, and cognitive characteristics
|
NOTCH3 carriers b (CADASIL) n=20 |
PSEN1 carriers a (ADAD) n=20 |
Non- carriers c n=45 |
||
|---|---|---|---|---|
| Demographics | ||||
| Age | 43.92 (6.89) | 37.80 (4.40) | 41.95 (7.16) | a<b * |
| Female, n (%) | 15 (75) | 9 (45) | 16 (36) | b>c ** |
| Education years | 9.65 (4.36) | 8.75 (3.46) | 9.27 (4.72) | |
| Cardiovascular risk factors | ||||
| Systolic BP | 122.05 (14.56) | 117.0 (9.27) | 120.35 (14.18) | |
| Hypertension treatment, n (%) | 3 (15) | 0 (0) | 5 (25) | |
| Diabetes, n (%) | 0 (0) | 0 (0) | 0 (0) | |
| BMI | 26.87 (3.92) | 26.04 (6.71) | 26.05 (4.47) | |
| Tobacco use, n (%) | 2 (10) | 7 (35) | 10 (22) | |
| FCRP score | 4.77 (3.77) | 3.72 (2.62) | 4.72 (3.91) | |
| Neuropsychological performance | ||||
| MMSE | 28.80 (2.42) | 28.05 (1.00) | 29.22 (0.85) | a<c ** |
| CERAD Total Score | 76.90 (10.41) | 76.70 (8.89) | 82.31 (7.44) | a<c ** , b<c ** |
| Memory Composite | −0.62 (1.24) | −0.83 (1.18) | 0.00 (0.79) | a<c ** , b<c * |
| Language Composite | −0.36 (1.39) | −0.25 (0.92) | 0.00 (0.85) | |
| Processing Composite | −1.01 (2.29) | −0.21 (0.52) | 0.00 (0.88) | b<c ** |
| Executive Function Composite | −0.98 (1.55) | −0.16 (0.72) | 0.00 (0.70) | b<a * , b<c *** |
Presented values are mean ± SD, unless otherwise specified. n (%) = number of subjects presenting with the listed condition (representative percentage of the group). Group differences on continuous variable (age, years of education, systolic blood pressure, body-mass index -BMI) were assessed using one-way ANOVAs, with the Bonferroni’s post-hoc tests. Group differences on dichotomous variables (sex, hypertension treatment, diabetes, and tobacco use) were assessed using chi-square tests. Group differences on the Framingham Risk Profile (FCRP) score were assessed using an ANCOVA, controlling for age and sex, with the Bonferroni’s post-hoc tests. Group differences in cognitive performance (MMSE, CERAD Total Score and domain-specific cognitive scores) were assessed using ANCOVAs, controlling for age and education, with the Bonferroni’s post-hoc tests. Because domain-specific cognitive scores were obtained using the performance of the non-carriers group as a reference, the mean for non-carriers on all domain-specific composite scores is 0.
presymptomatic Autosomal dominant Alzheimer’s Disease (ADAD) group
presymptomatic CADASIL group
non-carriers group
p<0.05
p<0.01
p<0.001