. Author manuscript; available in PMC: 2022 Nov 19.

Published in final edited form as: J Alzheimers Dis. 2021;82(2):841–853. doi: 10.3233/JAD-210313

Table 3 -.

Summary of regression models for the prediction of cognitive performance

		NOTCH3 carriers (CADASIL) n=20	PSEN1 carriers (ADAD) n=20	Non- carriers n=45
MMSE	Model Fit	R² = .48 ^*	R² = .22	R² = .08
	Age (B)	−.20 [−.40, .01]	−.03 [−.17, .11]	.01 [−.04, .06]
	Education (B)	.10 [−.22, .41]	.13 [−.02, .27]	.05 [−.01, .112]
	FCRP (B)	.01 [−.29, .30]	.12 [−.11, .35]	.01 [−.08, .10]
CERAD Total Score	Model Fit	R² =.54 ^**	R² =.40 ^*	R² =.59 ^***
	Age (B)	−.61 [−1.44, 1.19]	−.48 [−1.58, .64]	−.29 [−.59, .004]
	Education (B)	.93 [−.36, 2.21]	1.36^* [.22, 2.50]	1.04^** [.69, 1.38]
	FCRP (B)	.003 [−1.19, 1.19]	.17 [−1.66, 1.99]	.30 [−.21, .80]
Memory Composite	Model Fit	R² = .22	R² = .41 ^*	R² = .30 ^***
	Age (B)	−.06 [−.19, .07]	−.10 [−.24, .05]	.001 [−.04, .04]
	Education (B)	−.02 [−.22, .18]	.14 [−.01, .29]	.09^*** [.05, .14]
	FCRP (B)	−.09 [−.27, .09]	.001 [−.24, .24]	−.001 [−.07, .07]
Language Composite	Model Fit	R² =.64 ^***	R² =.42 ^*	R² =.59 ^***
	Age (B)	−.06 [−.15, .04]	.04 [−.08, .15]	−.04^* [−.07, −.001]
	Education (B)	.22^** [.07, .37]	.18^** [.07, .30]	.11^*** [.08, .15]
	FCRP (B)	.11 [−.03, .25]	.03 [−.15, .22]	.05 [−.01, .11]
Processing Speed Composite	Model Fit	R² =.63 ^***	R² =.64 ^***	R² =.57 ^***
	Age (B)	−.19^* [−.36, −.03]	−.02 [−.07, .03]	−.05^* [−.08, −.01]
	Education (B)	.15 [−.11, .40]	.12^*** [.07, .17]	.09^*** [.05, .13]
	FCRP (B)	.03 [−.20, .27]	.02 [−.06, .10]	−.01 [−.07, .05]
Executive Function Composite	Model Fit	R² =.74 ^***	R² =.76 ^***	R² =.55 ^***
	Age (B)	−.13^** [−.22, −.04]	−.05 [−.11, .005]	−.04^** [−.07, −.02]
	Education (B)	.12 [−.02, .26]	.17^*** [.11, .23]	.08^*** [.04, .11]
	FCRP (B)	.005 [−.13, .14]	.07 [−.03, .16]	.06^*[.01, .11]

Summary of general linear regression models evaluating the predictive value of the non-laboratory Framingham Risk Profile score (FCRP score), age, and education with regards to cognitive performance in each group. For each variable included in the models, the presented value is the Unstandardized B Coefficient [95% Confidence Intervals]. MMSE= Mini-Mental State Examination; CERAD Total Score = total score on the neuropsychological battery of the Consortium to Establish a Registry for Alzheimer's Disease; Proc. Speed=processing speed.

^{* =}

p<.05

^{** =}

p<.01

^{*** =}

p<.001.