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. 2022 Nov 8;7(21):e157034. doi: 10.1172/jci.insight.157034

Figure 1. A broader Ab response is induced by the wP prime vaccination.

Figure 1

(A) Blood was collected at day 0, day 14, and day 30 from AID-Cre-EYFP mice s.c. injected with aP or wP vaccines or with alum (ctr, control mice). IgM, IgG1, and IgG2b serum Ab titers against pooled proteins of the aP vaccine (PT, PRN, FHA, Fim2,3) (B) and IgM, IgG1, IgG2b, IgG2c, and IgG3 serum Ab titers against sonicated Bp (C) were detected by ELISA from serum of vaccinated and control mice. Ab titers are arbitrary values and each point in the graphs represents individual mouse data. At least 2 independent experiments were performed for each analysis. Means (±SEM) are shown. Kruskal-Wallis analysis with uncorrected Dunn’s test was performed to compare the different conditions at each time point and the different time points between the same conditions. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.