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. 2022 Oct 10;7(19):e159357. doi: 10.1172/jci.insight.159357

Figure 3. Transcriptomic findings are extended to additional DM1 models in vitro and in vivo.

Figure 3

(A) qPCR analysis of the indicated genes in PBMCs from DM1 and controls in PBMCs derived from patients with DM1 (n ≥ 56) and controls (n ≥ 22) (each point represents an independent sample). (B) qPCR analysis of KCND2 in PBMCs. (C) Measurement of mRNA levels of indicated genes by qPCR in early-passage myoblasts (n ≤ 7) derived from patients with DM1 and controls (each point represents an independent experiment). (D and E) Measurement of mRNA levels of indicated genes by qPCR in tibialis anterior muscle of 2-month-old DMSXL and control mice (n ≤ 6). P values were calculated using the Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001.