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. 2022 Nov 8;7(21):e154948. doi: 10.1172/jci.insight.154948

Figure 7. GINS4-KD in CD34+ hematopoietic precursors impairs NK cell maturation.

Figure 7

(A) GINS4 expression measured by qPCR in differentiating cells at day 21 and 28 of differentiation showing technical triplicates ± SD from the 2nd and 3rd experiments, respectively. (B) Evaluation of off-target effect on other GINS by qPCR analysis of GINS4-KD differentiating CD34+. (C) Representative flow plots of NK cell terminal differentiation of 3 independent experiments. (D) Relative frequency of CD45+CD3− differentiating NK cells in each maturation stage as previously described (Supplemental Figure 8). Data show mean ± SD of 3 independent experiments. P ≤ 0.05 by paired 2-tailed t test. (E) Percentage of CD45+CD3− cells in GINS4-KD condition compared with the control. Data shown are mean ± SD from 3 independent experiments.