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. 2022 Oct 10;7(19):e160885. doi: 10.1172/jci.insight.160885

Figure 6. SGK1 genetic inhibition prevents obesity-induced atrial inflammatory signaling.

Figure 6

(A) Atrial inflammatory gene transcript levels. One-way ANOVA, Dunnett’s test. *P < 0.05, **P < 0.01, ***P < 0.001. (B) Atrial macrophage content in lean and obese atria as measured by flow cytometry. One-way ANOVA. (C) Caspase-1 activity in obese atrial tissue as measured with a commercially available assay. Unpaired Student’s t test. *P < 0.05. (D) Western blots of atrial NLRP3 and caspase subunits with quantification below. One-way ANOVA, Dunnett’s test. *P < 0.05. (E) Western blots of atrial NF-κB subunit p65 and its phosphorylated isoform with quantification below. One-way ANOVA, Dunnett’s test. *P < 0.05, **P < 0.01. Number of mice in each group is represented by the number of dots in individual figure.