Figure 4. IgG+ PCs and local IgG are signatures of human BOS.
(A) Immunofluorescence staining of IgA and CD38 in healthy donor and BOS tissue samples and staining of IgG and CD38 in healthy and BOS tissue samples (samples from the University of Colorado collection). Scale bars, 25 μm. (B) Quantification of the local Ig profile in BALF samples from patients with and without BOS after LTx (University of South Florida/Tampa General Hospital LTx cohort). Data are presented as mean ± SEM and analyzed with a Mann-Whitney unpaired, 2-tailed test. *P < 0.05; ***P < 0.001.