Figure 2. Overexpression of hTS accelerates PanNET progression in mice with conditional Men1 knockout.

(A) Representative H&E images and photographs of pancreatic lesions developed in hTS/Men1^–/– mice (scale bars: 100 μm). (B) Immunoblot analysis of hTS in carcinoma isolated from hTS/Men1^–/– and Men1^–/– mice. (C) Comparison of adenoma and carcinoma incidence in Men1^–/– and hTS/Men1^–/– mice at 5, 6.5, and 8 months (from data shown in Supplemental Table 1). (D) Comparison of carcinoma incidence in Men1^–/– and hTS/Men1^–/– mice sacrificed at defined time points combined with mice sacrificed at end point. In C and D, significance was calculated using χ² test, *P < 0.05.