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. 2022 Sep 22;7(18):e156549. doi: 10.1172/jci.insight.156549

Figure 6. In vivo verification of a combination treatment with chemical chaperones.

Figure 6

(A) Intraperitoneal glucose tolerance test (IP-GTT) with WT or Wfs1-KO mice at baseline and 1 month after feeding with either control chow or food containing 4-PBA: 0.338% and TUDCA: 0.225% (P+T chow). (B) AUCs of the IP-GTT (KO, Ctrl: n = 12; KO, P+T: n = 12; WT: n = 7; **P < 0.01 and ***P < 0.001 by 1-way ANOVA; ##P < 0.01 and ####P < 0.0001 by 1-way ANOVA compared with WT: Baseline; ††††P < 0.0001 by 1-way ANOVA compared with WT: 1 month).