Table 4.
Gene Ontology analysis of high expression genes in age-related macular degeneration (AMD)
| Category | ID | Description | Count | BgRatio% | P | FDR |
|---|---|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO: 0006260 | DNA replication | 26 | 0.033041887 | 9.43E-13 | 1.62E-09 |
| GOTERM_BP_DIRECT | GO: 0000082 | G1/S transition of mitotic cell cycle | 20 | 0.025416836 | 3.94E-11 | 6.78E-08 |
| GOTERM_BP_DIRECT | GO: 0006334 | Nucleosome assembly | 20 | 0.025416836 | 6.26E-10 | 1.08E-06 |
| GOTERM_BP_DIRECT | GO: 0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 13 | 0.016520943 | 4.90E-07 | 8.44E-04 |
| GOTERM_BP_DIRECT | GO: 0031145 | Anaphase-promoting complex-dependent catabolic process | 13 | 0.016520943 | 1.61E-06 | 0.002766187 |
| GOTERM_BP_DIRECT | GO: 0098609 | Cell-cell adhesion | 24 | 0.030500203 | 1.90E-06 | 0.003276923 |
| GOTERM_BP_DIRECT | GO: 0006342 | Chromatin silencing | 10 | 0.012708418 | 3.13E-06 | 0.005379374 |
| GOTERM_BP_DIRECT | GO: 0060968 | Regulation of gene silencing | 6 | 0.007625051 | 6.28E-06 | 0.010812163 |
| GOTERM_BP_DIRECT | GO: 0051437 | Positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition | 12 | 0.015250102 | 7.08E-06 | 0.012186408 |
| GOTERM_BP_DIRECT | GO: 0007049 | Cell cycle | 20 | 0.025416836 | 9.56E-06 | 0.016458974 |
| GOTERM_BP_DIRECT | GO: 0006335 | DNA replication-dependent nucleosome assembly | 8 | 0.010166734 | 2.14E-05 | 0.036889283 |
| GOTERM_CC_DIRECT | GO: 0005654 | Nucleoplasm | 153 | 0.194438796 | 5.12E-20 | 7.32E-17 |
| GOTERM_CC_DIRECT | GO: 0000786 | Nucleosome | 24 | 0.030500203 | 2.48E-16 | 3.22E-13 |
| GOTERM_CC_DIRECT | GO: 0070062 | Extracellular exosome | 134 | 0.170292802 | 3.24E-12 | 4.63E-09 |
| GOTERM_CC_DIRECT | GO: 0005829 | Cytosol | 144 | 0.18300122 | 3.46E-10 | 4.94E-07 |
| GOTERM_CC_DIRECT | GO: 0000788 | Nuclear nucleosome | 13 | 0.016520943 | 1.00E-09 | 1.43E-06 |
| GOTERM_CC_DIRECT | GO: 0000784 | Nuclear chromosome, telomeric region | 20 | 0.025416836 | 1.50E-09 | 2.14E-06 |
| GOTERM_CC_DIRECT | GO: 0005634 | Nucleus | 201 | 0.255439203 | 1.66E-08 | 2.37E-05 |
| GOTERM_CC_DIRECT | GO: 0005737 | Cytoplasm | 195 | 0.247814152 | 2.08E-08 | 2.97E-05 |
| GOTERM_CC_DIRECT | GO: 0005913 | Cell-cell adherens junction | 26 | 0.033041887 | 1.79E-06 | 0.002553987 |
| GOTERM_CC_DIRECT | GO: 0000228 | Nuclear chromosome | 10 | 0.012708418 | 9.26E-06 | 0.013223895 |
| GOTERM_CC_DIRECT | GO: 0043234 | Protein complex | 28 | 0.035583571 | 1.54E-05 | 0.021938197 |
| GOTERM_CC_DIRECT | GO: 0000502 | Proteasome complex | 10 | 0.012708418 | 2.62E-05 | 0.037441779 |
| GOTERM_CC_DIRECT | GO: 0005739 | Mitochondrion | 61 | 0.07752135 | 3.35E-05 | 0.047910907 |
| GOTERM_MF_DIRECT | GO: 0005515 | Protein binding | 325 | 0.413023587 | 2.14E-14 | 3.20E-11 |
| GOTERM_MF_DIRECT | GO: 0098641 | Cadherin binding involved in cell-cell adhesion | 27 | 0.034312729 | 1.63E-07 | 2.44E-04 |