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. 2022 Nov 8;7(21):e162968. doi: 10.1172/jci.insight.162968

Figure 3. Intact and defective (3′ and 5′) provirus frequencies per million CD4+ T cells following kidney transplant.

Figure 3

(A) Intact and (B) defective provirus per million CD4+ T cells were measured longitudinally from time since transplant among patients who received lymphocyte-depleting or -nondepleting treatment. Each line represents an individual, and each dot represents a time point. Blue and red lines represent the locally estimated scatter plot smoothing (LOESS) curve for lymphocyte-depleting and -nondepleting groups, respectively. Gray shaded areas represent the 95% CI of the LOESS curves. (C and D) Comparisons between therapy groups were further analyzed and subdivided into time bins. Each dot represents an individual analyzed within a time bin. Box plots represent the IQR. Medians are represented by horizontal lines in the boxes. The lower and upper whiskers represent 1.5 times the IQR beyond the quartiles. P values were estimated by Wilcoxon’s rank-sum test.