Figure 4. Change in brain insulin action after an 8-week exercise intervention associates with hunger ratings and metabolic measures.

(A) The y axis displays the change in right putamen blood flow in response to intranasal insulin from before to after the exercise intervention (ΔCBF_post-8-week – ΔCBF_pre). The x axis shows the change in hunger ratings in response to intranasal insulin (ΔVAS_post-8-week – ΔVAS_pre). (B) The fold change of visceral adipose tissue from before to after the 8-week exercise intervention. (C) The fold change of maximal coupled skeletal muscle mitochondrial respiration in skeletal muscle fibers from before to after the 8-week exercise intervention. CBF, cerebral blood flow; VAS, visual analogue scale.