Table 2.
Structural evaluations of detrimental mutants of ADAM33 protein by different online software.
| SNP ID | AAS | MutPred2 Score1 | I-MUTANT2.0 | MuPro | ||
|---|---|---|---|---|---|---|
| Stability | RI2 | Stability | delG3 | |||
| rs773091023 | P678L | 0.64 | Decreased | 5 | Increased | 0.11 |
| rs764301730 | C671R | 0.93 | Decreased | 5 | Decreased | -1 |
| rs751597707 | C669G | 0.89 | Decreased | 8 | Decreased | -2.02 |
| rs368984072 | G661R | 0.84 | Decreased | 7 | Decreased | -0.62 |
| rs777553708 | C637Y | 0.62 | Decreased | 3 | Decreased | -0.65 |
| rs1334863089 | C631F | 0.91 | Decreased | 3 | Decreased | -0.06 |
| rs754867141 | C606S | 0.93 | Decreased | 7 | Decreased | -1.47 |
| rs754867141 | C606Y | 0.93 | Decreased | 3 | Decreased | -1 |
| rs915448220 | C573Y | 0.93 | Increased | 1 | Decreased | -0.75 |
| rs1432549895 | C519R | 0.93 | Decreased | 2 | Decreased | -0.93 |
| rs1262246273 | Y513C | 0.93 | Decreased | 6 | Decreased | -1.14 |
| rs1203116461 | P496L | 0.84 | Decreased | 8 | Decreased | -0.23 |
| rs757567846 | D483A | 0.84 | Decreased | 4 | Decreased | -1.01 |
| rs1424975479 | C482F | 0.93 | Decreased | 5 | Decreased | -0.51 |
| rs1165412077 | C482S | 0.93 | Decreased | 6 | Decreased | -1.22 |
| rs779669835 | R476C | 0.92 | Decreased | 4 | Decreased | -0.33 |
| rs748720838 | C475G | 0.92 | Decreased | 7 | Decreased | -1.66 |
| rs528261077 | G472V | 0.92 | Decreased | 3 | Decreased | -0.07 |
| rs1378161696 | C463Y | 0.92 | Decreased | 2 | Decreased | -0.77 |
| rs768654352 | G460R | 0.87 | Decreased | 7 | Decreased | -0.63 |
| rs1192357091 | C444S | 0.92 | Decreased | 6 | Decreased | -1.29 |
| rs1192357091 | C444Y | 0.90 | Decreased | 4 | Decreased | -0.84 |
| rs777252478 | C439Y | 0.92 | Decreased | 2 | Decreased | -0.56 |
| rs1321728445 | C431S | 0.92 | Decreased | 5 | Decreased | -1.46 |
| rs747255442 | G428C | 0.92 | Decreased | 4 | Decreased | -0.12 |
| rs776082098 | C420Y | 0.93 | Decreased | 3 | Decreased | -1.05 |
| rs751613984 | C388Y | 0.93 | Decreased | 4 | Decreased | -0.95 |
| rs1313175203 | C371Y | 0.64 | Decreased | 0 | Decreased | -0.83 |
| rs764090883 | C371R | 0.78 | Decreased | 2 | Decreased | -0.8 |
| rs1297854732 | C360R | 0.91 | Decreased | 5 | Decreased | -1.06 |
| rs1351880201 | D219V | 0.92 | Decreased | 3 | Decreased | -0.62 |
1Scores higher than 0.5 indicate pathogenicity. 2RI stands for reliability index of prediction. 3delG values under zero designate protein destabilization.