Table 3.
Structural evaluations of detrimental mutants of ADAM33 protein by SNPeffect 4.0 web server.
| SNP ID | AAS | TANGO | WALTS | LIMBO | FoldX |
|---|---|---|---|---|---|
| rs773091023 | P678L | No effect | No effect | No effect | Not available |
| rs764301730 | C671R | No effect | No effect | No effect | Not available |
| rs751597707 | C669G | No effect | No effect | No effect | Not available |
| rs368984072 | G661R | No effect | No effect | No effect | Not available |
| rs777553708 | C637Y | No effect | No effect | No effect | Not available |
| rs1334863089 | C631F | No effect | No effect | No effect | Not available |
| rs754867141 | C606S | No effect | No effect | No effect | Not available |
| rs754867141 | C606Y | No effect | No effect | No effect | Not available |
| rs915448220 | C573Y | No effect | No effect | No effect | Not available |
| rs1432549895 | C519R | No effect | No effect | No effect | Not available |
| rs1262246273 | Y513C | No effect | No effect | No effect | Not available |
| rs1203116461 | P496L | No effect | No effect | No effect | Not available |
| rs757567846 | D483A | No effect | No effect | No effect | Not available |
| rs1424975479 | C482F | No effect | No effect | No effect | Not available |
| rs1165412077 | C482S | No effect | No effect | No effect | Not available |
| rs779669835 | R476C | No effect | No effect | No effect | Not available |
| rs748720838 | C475G | No effect | No effect | No effect | Not available |
| rs528261077 | G472V | No effect | No effect | No effect | Not available |
| rs1378161696 | C463Y | No effect | No effect | No effect | Not available |
| rs768654352 | G460R | No effect | No effect | No effect | Not available |
| rs1192357091 | C444S | No effect | No effect | No effect | Not available |
| rs1192357091 | C444Y | No effect | Increases amyloid propensity | No effect | Not available |
| rs777252478 | C439Y | No effect | No effect | No effect | Not available |
| rs747255442 | G428C | No effect | No effect | No effect | Not available |
| rs747255442 | G428C | No effect | No effect | No effect | Not available |
| rs776082098 | C420Y | No effect | No effect | No effect | Not available |
| rs751613984 | C388Y | No effect | Increases amyloid propensity | No effect | Reduce stability |
| rs1313175203 | C371Y | No effect | No effect | No effect | Severely reduce stability |
| rs764090883 | C371R | No effect | No effect | No effect | Severely reduce stability |
| rs1297854732 | C360R | No effect | No effect | No effect | Reduce stability |
| rs1351880201 | D219V | Increased aggregation tendency | Decreases amyloid propensity | No effect | Severely reduce stability |