Table 5.
Ligand-binding site prediction of ADAM33 protein, obtained from RaptorX binding server.
| Domain | P value | uGDT (GDT) | uSeqId (SeqId) | Multiplicity | Ligand | Binding residues | |
|---|---|---|---|---|---|---|---|
| 1 (residues 199-414) | 4.79e − 09 | 4.79e − 09 | 205 (95) | 1 | 150 | ZN | A309 T310 V311 G312 L313 T342 H345 E346 H349 H355 A374 A375 A376 T377 |
| 2 | 71 | CA | E213 D296 N407 | ||||
|
| |||||||
| 2 (residues 69-198) | 7.79e − 03 | 52 (40) | 9 (7) | 1 | 9 | PO4 | E170 Q171 L172 L173 T174 |
| 2 | 9 | KDO | L172 L173 T174 W175 K176 | ||||
| 3 | 6 | FTT | G135 S137 Y149 R151 E165 F167 M169 E170 Q171 | ||||
| 4 | 6 | FTT | W127 S137 S147 Y149 M169 L172 | ||||
| 5 | 5 | OES | P99 Q102 P103 Q117 R119 | ||||
| 6 | 3 | OES | R121 P124 D125 S143 | ||||
|
| |||||||
| 3 (residues 1-68) | 2.69e − 02 | 23 (34) | 5 (7) | 1 | 1 | 7OD | L15 L19 T41 P42 |
|
| |||||||
| 4 (residues 415-690) | 7.54e − 21 | 182 (66) | 97 (35) | 1 | 16 | CA | L484 E486 D498 V499 |
| 2 | 15 | CA | L419 N422 F424 E426 E429 D432 | ||||
| 3 | 5 | MAN | G480 D481 | ||||
ZN: zinc ion; CA: calcium ion; PO4: phosphate ion; KDO: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid; FTT: 3-hydroxy-tetradecanoic acid; OES: N-octyl-2-hydroxyethyl sulfoxide; 7OD: (2E,5R)-5-hydroxy-2-methylhept-2-enoic acid; MAN: alpha-D-mannopyranose.