Table 3.
Univariable and multivariable risk models of prostate cancer progression of population and age subgroups including patients treated with robot-assisted radical prostatectomy
| Clinical model | Population (n = 901) | Age < 70 years (n = 658) | Age > / = 70 years (n = 243) | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| EAU Intermediate-risk class | ||||||
| Univariable analysis | 2.307 (1.379–3.862) | 0.001 | 2.434 (1.345–4.404) | 0.003 | 1.955 (0.692–5.528) | 0.206 |
| Multivariable analysis | 2.143 (1.276–3.600) | 0.004 | 2.200 (1.209–4.006) | 0.010 | 1.931 (0.681–5.472) | 0.216 |
| EAU high-risk class | ||||||
| Univariable analysis | 4.590 (2.632–8.004) | < 0.0001 | 4.224 (2.182–8.176) | < 0.0001 | 5.300 (1.814–15.237) | 0.002 |
| Multivariable analysis | 3.848 (2.177–6.802) | < 0.0001 | 3.487 (1.776–6.487) | < 0,0001 | 5.029 (1.685–15.010) | 0.004 |
| BPC ≥ 50% | ||||||
| Univariable analysis | 2.208 (1.539–3.168) | < 0.0001 | 2.442 (1.595–3.740) | < 0.0001 | 1.705 (0.863–3.367) | 0.125 |
| Multivariable analysis | 1.780 (1.244–2.590) | 0.003 | 2.062 (1.352–3.194) | 0.001 | 1.146 (0.548–2.309) | 0.717 |
| Pathological model | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
|---|---|---|---|---|---|---|
| ISUP > 2 | ||||||
| Univariable analysis | 4.080 (2.764–6.023) | < 0.0001 | 3.742 (2.418–5.792) | < 0.0001 | 6.532 (2.474–17.248) | < 0.0001 |
| Multivariable analysis | 2.742 (1.811–4.152) | < 0.0001 | 2.654 (1.663–4.235) | < 0.0001 | 4.261 (1.541–11.770) | 0.005 |
| Seminal vesicle invasion | ||||||
| Univariable analysis | 5.253 (3.416–8.078) | < 0.0001 | 6.244 (3.629–10.743) | < 0.0001 | 4.016 (1.935–8.336) | < 0.0001 |
| Multivariable analysis | 2.368 (1.432–3.915) | 0.001 | 3.038 (1.615–5.715) | 0.001 | 1.565 (0.655–3.741) | 0.314 |
| Positive surgical margins | ||||||
| Univariable analysis | 2.277 (1.579–3.283) | < 0.0001 | 2.397 (1.559–3.686) | < 0.0001 | 1.989 (0.990–3.995) | 0.050 |
| Multivariable analysis | 1.684 (1.130–2.510) | 0.010 | 1.833 (1.148–2.924) | 0.011 | 1.201 (0.545–2.645) | 0.650 |
| Pelvic lymph node invasion | ||||||
| Univariable analysis | 7.211 (4.348–11.960) | <0.0001 | 6.041 (3.269–11.163) | < 0.0001 | 10.500 (4.219–26.131) | < 0.0001 |
| Multivariable analysis | 2.912 (1.628–5.208) | 0.010 | 2.073 (1.000–4.300) | 0.050 | 5.626 (2.041–15.512) | 0.001 |