Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 19;13:7115. doi: 10.1038/s41467-022-34810-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a TEMR events are classified by breakpoint characteristics guided by TE consensus sequences. For homologous breakpoints, the chimeric TE resulting from the TEMR event must reconstruct a full TE with microhomology at the breakpoint. HR, homologous recombination; NHE, non-homologous repair; TE, transposable element; SV, structural variant; MEI, mobile element insertion, TEMR, transposable element-mediated rearrangement; LINE; long interspersed nuclear element. b An example of TEMR-HR (top). Breakpoint junction of 1,294 bp TEMR deletion in NA19240 (middle) and alignment between flanking Alu elements to a Alu consensus sequence (bottom). c An example of TEMR-NHE (top). Breakpoint junction of 312 bp TEMR deletion in HG00514 (middle) and alignment between flanking Alu elements to a Alu consensus sequence (bottom). REF, reference genome (GRCh38). d The breakpoint microhomology distribution differs between NHE (orange) and HR (blue) TEMRs. e top: Microhomology GC content distribution for Alu TEMRs (dark green, n = 330), reference Alu elements (light green, n = 1,181,072), LINE-1 TEMRs (dark purple, n = 38), reference LINE-1s (light purple, n = 962,085) and the full human genome reference (HGR, gray). Bottom: Average GC content of TEMR breakpoint microhomologies for Alu (green) and LINE-1 (purple) TEMRs. Microhomologies were restricted to 5+ bp for this analysis. A two-sided Welch’s t-test was used to calculate the p-value. n.s, not significant.