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. 2022 Nov 19;13:7120. doi: 10.1038/s41467-022-34400-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Mutations located in spike protein were identified in Omicron subvariants including BA.2, BA.4/5, and BA.2.75. Amino acid residues consistent with WT SARS-CoV-2 were marked in gray, and mutations in Omicron subvariants were marked in orange. b Schematic overview of study design. Blood samples from BA.2 breakthrough infected individuals previously immunized with 2-dose or 3-dose inactivated vaccines were collected in the early stage of infection (Visit 1, within 2 days after diagnosis) and during the convalescent period (Visit 2, 81 days post diagnosis).