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. 2022 Nov 19;13(11):976. doi: 10.1038/s41419-022-05413-4

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Dysfunction of BNIP3-dependent mitophagy induces cellular ROS accumulation that leads to p53-mediated ESC differentiation, and decreased ATP generation that results in compromised AMPK-dependent homologous recombination. Reinforcement of BNIP3-dependent mitophagy during reprogramming improves iPSC genomic integrity.