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. 2022 Nov 19;12:19912. doi: 10.1038/s41598-022-24284-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased numbers of astrocytes in the neocortex of adult Dyrk1a^+/− mice. (a) Schematic representation of a coronal brain section indicating the corpus callosum in grey and the region of the cerebral cortex for cell quantification (rectangle). (b) Brain sections from 2-month-old (2 M) Dyrk1a^+/+ (+/+) and Dyrk1a^+/− (+/−) mice stained for SOX9 and with the nuclei labelled by DAPI (blue). The position of the neocortical layers I to VI are indicated. (c) The number of SOX9⁺ astrocytes (mean ± SEM) in 500 μm wide columns. The values correspond to individual animals obtained from 2 litters: *P < 0.05, Student’s t-test. Scale bar: 100 μm.