Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 19;12:19912. doi: 10.1038/s41598-022-24284-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Alterations to the nodes of Ranvier in adult Dyrk1a^+/− mice. (a) Representative images from the corpus callosum of 2-month-old Dyrk1a^+/+ (+/+) and Dyrk1a^+/− (+ /−) mice showing the nodes of Ranvier labelled for NAV1.6 (red) and the paranodes for CASPR (green). (b) Density (mean ± SEM) of the nodes of Ranvier. The values correspond to the node density obtained from 16 (+/+) and 13 (+/−) images: ns, not significant, Student’s t-test. (c) Image showing a node of Ranvier and the intensity of CASPR staining in the paranodes. Green dots in the intensity profile represent the center of mass for each paranode as determined by the 3D object reconstruction. (d–f) Scatter dot plots showing the node length (d), intraparanodal length (e) and NAV1.6 labelling index (L.I.) (f) for individual nodes of Ranvier (n = 2–3 animals each genotype, 1 litter): 95 (+/+) and 100 (+/−) nodes in d; 356 (+/+) and 217 (+/−) in (e); 88 (+/+) and 90 (+/−) in (f); *P < 0.05 and **P < 0.01, Mann–Whitney U test; **P < 0.001, Student’s t-test.