Table 4. MF in the fabrication of NPs .

Process	Type of NP	Advantages	Reference
MF continuous flow	Crystalline drug NPs	Production of ultrafine homogeneous NPs Uniform encapsulation	99
Microfluidic nebulator in supersonic spray dryer	Amorphous drug NPs	Solubility enhancement Less tendency to re-crystallize Improved stability for hydrophobic molecules	100,101
MF channels with tunable hydrodynamic flow	Polymeric NPs	Classic hold on composition and processing parameters Good control on shape, size and encapsulation efficiency	102,103
MF device with a multi-inlet micromixer	Targeted NPs	Enables employment of targeting ligands at different ligand densities and production of homogeneous tunable NPs	104,105
Droplet MFs	NPs in microsphere	Very high encapsulation efficiency with the use of nanoliters of immiscible solutions for production of homogeneous nanotube loaded microparticles for Dual drug delivery and sustained action	106,107