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. 2022 Nov 19;16:60. doi: 10.1186/s40246-022-00434-8

Table 1.

Comparison of laboratory parameters between deceased and recovered patients infected with COVID-19

Variables Deceased patients (n = 1149) Recovered patients (n = 1342) P-value
Mean age ± SD 59.3 ± 10.9 51.0 ± 13.0 < 0.001*
Gender (male/female) 611/538 (53.2/46.8%) 697/645 (51.9/48.1%) 0.537
ALT, IU/L (mean ± SD) (Reference range: 5–40) 44.5 ± 23.9 33.2 ± 24.3 < 0.001*
AST, IU/L (mean ± SD) (Reference range: 5–40) 36.9 ± 13.0 31.3 ± 15.7 < 0.001*
ALP, IU/L (mean ± SD) (Reference range: up to 306) 201.9 ± 66.3 171.0 ± 90.6 < 0.001*
Cholesterol, mg/dL (mean ± SD) (Reference range: 50–200) 116.6 ± 38.9 121.8 ± 36.3 < 0.001*
TG, mg/dL (mean ± SD) (Reference range: 60–165) 116.6 ± 41.7 131.5 ± 61.5 < 0.001*
LDL, mg/dL (mean ± SD) (Reference range: up to 150) 70.2 ± 35.6 107.1 ± 49.3 < 0.001*
HDL, mg/dL (mean ± SD) (Reference range: > 40) 30.6 ± 10.9 34.4 ± 11.6 < 0.001*
WBC, 109/L (mean ± SD) (Reference range: 4000–10,000) 7544.4 ± 2663.4 7717.4 ± 2897.6 0.347
CRP, mg/L (mean ± SD) (Reference range: < 10 mg/L Negative) 67.3 ± 21.4 56.9 ± 20.9 < 0.001*
ESR, mm/1st h (mean ± SD) (Reference range: 0–15) 54.5 ± 15.6 46.5 ± 15.3 < 0.001*
FBS, mg/dL (mean ± SD) (Reference range: 70–100) 110.7 ± 42.9 105.6 ± 41.3 < 0.001*
Platelets × 1000/cumm (mean ± SD) (Reference range: 140,000–400,000) 186 ± 76 185 ± 65 0.206
Uric acid, mg/dL (mean ± SD) (Reference range: 3.6–6.8) 3.9 ± 1.2 5.6 ± 1.4 < 0.001*
Creatinine, mg/dL (mean ± SD) (Reference range: 0.6–1.4) 1.2 ± 0.3 0.7 ± 0.2 < 0.001*
T3, ng/dL (mean ± SD) (Reference range: 2.3–4.2) 3.1 ± 1.2 2.5 ± 0.8 0.061
T4, mcg/dL (mean ± SD) (Reference range: 5.6–13.7) 8.9 ± 4.6 8.3 ± 3.3 0.091
TSH, mu/L (mean ± SD) (Reference range: 0.4–4.5) 3.5 ± 1.4 3.3 ± 1.2 0.384
25-hydroxy vitamin D, ng/mL (mean ± SD) (Normal range: 21–150) 25.3 ± 10.1 35.9 ± 13.4 < 0.001*
SARS-CoV-2 variants < 0.001*
 Alpha 396 (48.1%) 427 (51.9%)
 Delta 664 (75.3%) 218 (24.7%)
 Omicron BA.5 89 (11.2%) 697 (88.8%)
IFITM3 rs6598045 < 0.001*
 AA 190 (17.5%) 897 (82.5%)
 AG 508 (60.6%) 330 (39.4%)
 GG 451 (79.7%) 115 (20.3%)

COVID-19 coronavirus disease 2019, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, TG triglyceride, LDL low density lipoprotein, HDL high density lipoprotein, WBC white blood cells, CRP C-reactive protein, ESR erythrocyte sedimentation rate, FBS fasting blood glucose, T3 triiodothyronine, T4 thyroxine, TSH thyroid-stimulating hormone, SD standard deviation, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, IFITM3 interferon-induced transmembrane protein 3.

*Statistically significant (< 0.05)