. Author manuscript; available in PMC: 2023 Jul 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2022 Apr 28;221:106121. doi: 10.1016/j.jsbmb.2022.106121

Table 5.

IC₅₀ for indomethacin for all AKR1C3 variants.

Variant	Indomethacin IC₅₀ for S-tetralol oxidation (μM)	Indomethacin IC₅₀ for 4AD reduction (μM)
WT	0.12 ± 0.011	0.41 ± 0.031
H5Q	0.11 ± 0.0067	0.42 ± 0.031
E77G	0.12 ± 0.013	0.41 ± 0.017
K104D	0.091 ± 0.0086	0.42 ± 0.034
R258C	0.089 ± 0.019^*	0.46 ± 0.019

For all analyses

p < 0.05

^**

p < 0.01

^***

p < 0.001

^****

p < 0.0001.