Table 2.
Demographics and clinical characteristics of patients with positive Tc-99m pyrophosphate (PYP) imaging versus patients with negative imaging
| Variable | PYP group | P-value | |
|---|---|---|---|
| Positive (N = 62) | Negative (N = 20) | ||
| Age at PYP scan (years) | 76 ± 7.3 | 68 ± 12.4 | <0.001 |
| BMI (kg/m2) | 27.2 ± 3.8 | 30.2 ± 5.4 | 0.008 |
| Male | 55 (89%) | 17 (85%) | 0.700 |
| Black | 17 (28%) | 10 (50%) | 0.056 |
| Hispanic | 7 (11%) | 1 (5%) | |
| White | 33 (53%) | 9 (45%) | |
| Hemoglobin (g/dL) | 13.2 (12.1–14.5) | 12.7 (11.1–14.6) | 0.44 |
| Creatinine (mg/dL) | 1.21 (1.08–1.48) | 1.18 (1.08–1.82) | 0.77 |
| eGFR (mL/min/1.73m2) | 63.5 ± 21.14 | 59.5 ± 32.92 | 0.52 |
| Troponin (ng/mL) | 0.12 (0.06–0.18) | 0.06 (0.01–0.08) | 0.003 |
| NT-ProBNP (pg/mL) | 2030 (1146–3722) | 754 (206–3041) | 0.072 |
| BNP (pg/mL) | 381 (240–757) | 336 (190–1028) | 0.85 |
| Prealbumin (mg/dL) | 20.8 ± 6.84 | 25 ± 7.39 | 0.100 |
| AST (U/L) | 28 (21–35) | 27 (19–30) | 0.72 |
| ALT (U/L) | 24 (19–32) | 3 (18–32) | 0.92 |
| Total bilirubin (mg/dL) | 0.8 (0.6–1.2) | 0.7 (0.5–0.9) | 0.081 |
| Alkaline phosphatase (U/L) | 90 (72–122) | 82 (72–95) | 0.23 |
| Echocardiography | |||
| Left atrial size (mm) | 42.2 ±6.5 | 42.1 ± 9.7 | 0.96 |
| Septal wall thickness (mm) | 15.1 ± 2.9 | 13.8 ± 4.5 | 0.13 |
| Inferolateral wall thickness (mm) | 15 ± 3.1 | 12 ± 2.3 | <0.001 |
| Left ventricular mass (g) | 277.5 ± 74.7 | 229 ± 68.6 | 0.015 |
| Left ventricular ejection fraction (%) | 49 ± 12 | 56 ± 12 | 0.019 |
| Electrocardiogram | |||
| Total voltage (mm) | 111 (92–141) | 133 (101–194) | 0.048 |
| Low voltage* | 5 (8%) | 1 (5%) | 1.00 |
Values are median (interquartile range), n (%), or mean ± standard deviation.
*
Low voltage defined as QRS amplitude of <5 millimeters in the limb leads and/or <10 millimeters in the precordial leads.