Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 16;15:2495–2506. doi: 10.2147/CCID.S374122

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Schlesinger et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Graphical summary of tirbanibulin mechanism of action (ATNXUS-KX01-001 study): representative summary of tirbanibulin described and potential mechanisms of action. Tirbanibulin inhibits tubulin polymerization, activating intrinsic and extrinsic apoptotic pathways of cancer cells inducing IL-α and P53. The disruption of the cytoskeleton leads to the arrest of the cell cycle via multiple factors (eg, CD1, FAK) and might affect Src intracellular trafficking (FAK, Rho and GEF-H1) and Src-mediated signaling (FAK, paxillin, Rho, p130, p120) causing the inhibition of p-Src and metastasis. This figure was created with “BioRender.com”.

Abbreviations: FAK, focal adhesion kinase; GEF-H1, guanine exchange factor H1; IL, interleukin; pSrc, phosphorylated Src.