Table 4.
Incidence rates of hospitalization of children/adolescents (< 18 years old) per 1000 all-cause hospitalizations and their 95% confidence interval from January/2019 to February/2022 in the Brazilian Public Health System.
| < 6 years-old | 6–11 years-old | 12–17 years-old | ||
|---|---|---|---|---|
| 2019 | Hepatitis of unknown etiology | 6.11 [5.98–6.25] | 12.76 [12.41–13.13] | 10.83 [10.56–11.11] |
| Viral Hepatitis A-E | 1.70 [1.63–1.78] | 4.81 [4.59–5.03] | 3.02 [2.88–3.17] | |
| Other infectious hepatitis | 1.93 [1.86–2.01] | 3.57 [3.38–3.76] | 2.56 [2.43–2.70] | |
| Other liver diseases | 17.75 [17.52–17.98] | 26.19 [25.68–26.72] | 23.07 [22.67–23.47] | |
| Complications of Liver Transplant | 5.29 [5.16–5.42] | 6.65 [6.39–6.92] | 5.41 [5.21–5.60] | |
| Adenovirus infection | 14.04 [13.83–14.25] | 7.70 [7.43–7.99] | 2.93 [2.79–3.08] | |
| SARS-CoV-2 infection | 312.73 [311.76–313.71] | 252.26 [250.66–253.87] | 189.62 [188.47–190.77] | |
| Other viral infection | 104.07 [103.51–104.64] | 423.71 [421.64–425.80] | 241.81 [240.51–243.12] | |
| 2020 | Hepatitis of unknown etiology | 8.72 [8.52–8.91] | 18.25 [17.73–18.77] | 13.23 [12.89–13.57] |
| Viral Hepatitis A-E | 2.43 [2.33–2.53] | 6.87 [6.56–7.19] | 3.69 [3.51–3.87] | |
| Other infectious hepatitis | 2.76 [2.65–2.87] | 5.10 [4.83–5.38] | 3.13 [2.97–3.29] | |
| Other liver diseases | 25.31 [24.98–25.65] | 37.45 [36.71–38.19] | 28.16 [27.68–28.66] | |
| Complications of Liver Transplant | 7.54 [7.36–7.73] | 9.51 [9.14–9.89] | 6.60 [6.37–6.84] | |
| Adenovirus infection | 20.02 [19.73–20.32] | 11.01 [10.61–11.42] | 3.58 [3.41–3.76] | |
| SARS-CoV-2 infection | 446.00 [444.61–447.40] | 360.62 [358.33–362.92] | 231.51 [230.11–232.92] | |
| Other viral infection | 148.42 [147.61–149.23] | 605.72 [602.75–608.69] | 295.24 [293.66–296.84] | |
| 2021 | Hepatitis of unknown etiology | 7.80 [7.63–7.98] | 17.96 [17.46–18.48] | 13.28 [12.95–13.62] |
| Viral Hepatitis A-E | 2.17 [2.08–2.27] | 6.76 [6.46–7.08] | 3.70 [3.53–3.89] | |
| Other infectious hepatitis | 2.47 [2.37–2.57] | 5.02 [4.75–5.29] | 3.14 [2.98–3.31] | |
| Other liver diseases | 22.65 [22.36–22.95] | 36.87 [36.15–37.60] | 28.28 [27.79–28.78] | |
| Complications of Liver Transplant | 6.75 [6.59–6.91] | 9.36 [9.00–9.737] | 6.63 [6.39–6.87] | |
| Adenovirus infection | 17.92 [17.66–18.19] | 10.84 [10.45–11.24] | 3.60 [3.42–3.78] | |
| SARS-CoV-2 infection | 399.15 [397.90–400.40] | 355.07 [352.82–357.33] | 232.45 [231.04–233.87] | |
| Other viral infection | 132.83 [132.11–133.55] | 596.39 [593.47–599.33] | 296.44 [294.85–298.04] | |
| 2022 | Hepatitis of unknown etiology | 7.52 [7.11–7.94] | 16.82 [15.68–18.03] | 13.96 [13.10–14.85] |
| Viral Hepatitis A-E | 2.10 [1.88–2.32] | 6.34 [5.64–7.09] | 3.89 [3.45–4.38] | |
| Other infectious hepatitis | 2.38 [2.15–2.62] | 4.70 [4.10–5.36] | 3.30 [2.89–3.75] | |
| Other liver diseases | 21.84 [21.14–22.55] | 34.53 [32.88–36.24] | 29.72 [28.46–31.02] | |
| Complications of Liver Transplant | 6.51 [6.13–6.90] | 8.77 [7.95–9.65] | 6.96 [6.36–7.61] | |
| Adenovirus infection | 17.27 [16.66–17.91] | 10.15 [9.27–11.10] | 3.78 [3.34–4.26] | |
| SARS-CoV-2 infection | 384.80 [381.86–387.76] | 332.54 [327.38–337.75] | 244.29 [240.67–247.96] | |
| Other viral infection | 128.05 [126.36–129.76] | 558.55 [551.86–565.30] | 311.54 [307.44–315.67] |
Disease categories were classified based on International Classification of Diseases (ICD-10) codes as hepatitis of unknown etiology (ICD-10: B19, B19.0, B19.9, K72.0, K72.9, K75.9, R94.5, K75 or R93.2); viral hepatitis A-E (ICD-10 codes: B15, B15.0, B15.9, B16, B16.0, B16.1, B16.2, B16.9, B17.0, B17.1 or B17.2); other infectious hepatitis (ICD-10 codes: A06.4, B17, B17.8, B25.1, B67.0, B67.5, B67.8, B94.2, O98.4 or P35.3); other liver diseases (ICD-10 codes: K72, K74.1, K75.2, K75.3, K75.4, K75.8, K76, K76.0, K76.1, K76.2, K76.3, K76.4, K76.5, K76.8, K76.9, K77, Q26.6, Q44, Q44.6 or Q44.7); adenovirus infection (ICD-10 codes: A08.2, A85.1, A87.1, B30.0, B30.1, B34.0, B97.0 or J12.0); COVID-19 (ICD-10 codes: B34.2, B97.2, U07.1, U07.2, U09.9, U10.9, U12.9 or U92.1); other viral infection (ICD-10 codes: B25.9, B25, B27.1, B25.8, B25.2, B25.0, A90, A91, D82.3, B30.3, A85.0, B97.1, B08.4, B08.5, A88.0, B34.1, A87.0, A08.1, A95, A95.9, A95.0, A95.1 or Z24.3); and complications of liver transplant (ICD-10 codes: T86.4 or Z94.4).