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Overview of cohort and experimental schematic
Whole blood samples were collected from three cohorts: (1) pediatric healthy controls, (2) pediatric acute COVID-19 infection, and (3) multisystem inflammatory syndrome in children (MIS-C). Plasma collected from whole-blood samples was used in proteomic assays to quantify levels of protein and cell-free DNA. Isolated neutrophils were used in bulk RNA sequencing and NETosis assays. Patient samples were used in individual or multiple assays.
