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. 2022 Nov 20;12:19977. doi: 10.1038/s41598-022-24170-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The scheme of arginine biosynthesis extracted from KEGG database²⁸ (Id hsa00220). Enzymes that can be the potential targets of viral proteins are shown by red boxes, the metabolites increased in the plasma of COVID-19 patients are underscored by red line, while those decreased are underscored by blue line.