Figure 2.

Comparative phase analysis of the averaged kinetic curves of clot contraction for patients with a MYH9 gene mutation (red, n = 3) and healthy subjects (black, n = 15). On the averaged kinetic curves (A) transitions between the phases of contraction were determined by finding local maxima and minima within the instantaneous first derivatives. The curves were fit using a piecewise function, and the rate constant of each phase was determined. Average rate constants of phases 1, 2, and 3 (B,C,D, respectively) are shown for patients with a MYH9 gene mutation (red) and healthy subjects (black). The results are presented as the median and interquartile range (25th and 75th percentiles). Mann–Whitney U test.