Table 4.
Flow cytometry-measured expression of active integrin αIIbβ3 (mAb PAC-1 binding) and P-selectin in resting and stimulated platelets from the blood of patients with a MYH9 gene mutation.
| Expression of active integrin αIIbβ3 | Expression of P-selectin | |||
|---|---|---|---|---|
| Resting platelets | TRAP-stimulated platelets | Resting platelets | TRAP-stimulated platelets | |
| Control heathy subjects (n = 10) |
1.8% (1.2; 2.0) |
92% (88; 92) |
1.1% (0.6; 1.8) |
79% (65; 81) |
| Proband M | 24% | 49% | 26% | 71% |
| Sister of proband A | 14% | 62% | 36% | 64% |
| Mother of proband F | 15% | 82% | 11% | 78% |
(1) Results are presented as fractions of platelets expressing active integrin αIIbβ3 or P-selectin; (2) the results for control heathy subjects are presented as the median and interquartile range (25th and 75th percentiles); (3) the numbers in bold are outside the normal ranges determined in control healthy subjects.