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. 2022 Nov 7;13:1023719. doi: 10.3389/fphar.2022.1023719

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Copyright © 2022 Yang, Liu, Li and Mo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HA@MOF@GSK-J1 affects a JMJD3-mediated gene network. (A) Heat-map of gene expression in CR SKOV-3 cells after different treatments (B) KEGG analysis of the biological pathways of the genes in regulated CR SKOV-3 cells following treatment with HA@MOF@GSK-J1 compared to treatment with MOF@GSK-J1 treated. (C) Histograms showing the RNA fold-induction of different treatments. qPCR analysis of CR SKOV-3 cells was performed using the indicated primers after different treatments (Supplementary Table S1). Amplification of GAPDH transcripts was used to normalize the loading of each RNA sample. (D) ChIP-qPCR analysis of H3K27me3 mark of the HER2, and MYCN promoters in CR SKOV-3 cells treated with different formulations. (E) Western blot analysis of HER2 in CR SKOV-3 cells after different treatments. All results are expressed as fold-inductions (means) from three independent experiments. The bars indicate SD (*p < 0.05, Student’s t-tests).