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. 2022 Nov 7;13:1030920. doi: 10.3389/fphys.2022.1030920

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Copyright © 2022 Pioner, Santini, Palandri, Langione, Grandinetti, Querceto, Martella, Mazzantini, Scellini, Giammarino, Lupi, Mazzarotto, Gowran, Rovina, Santoro, Pompilio, Tesi, Parmeggiani, Regnier, Cerbai, Mack, Poggesi, Ferrantini and Coppini.

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Effects of forskolin on calcium transients. Calcium transients of the before and after forskolin addition in day 60 control- and DMD-hiPSC-CMs. (A,B) Superimposed normalized traces of calcium transients recorded in the control hiPSC-CMs line, before and after treatment with forskolin (FSK, light green controls, dark green DMD), reported as the variation (%) compared with the basal condition. (C) Calcium transient amplitude is reported, during pacing at 1 Hz, as the % variation related to the basal condition compared to the treatment with FSK in DMD. (D) CaT decay (difference of 50% of CaT decay and TTP, RT50, ms) is reported, during pacing at 1 Hz, as the % variation related to the basal condition compared to the treatment with FSK in controls and DMD.